Histone methyltransferase SETD2 inhibits tumor growth via suppressing CXCL1-mediated activation of cell cycle in lung adenocarcinoma
You Zhou, Xiao Zheng, Bin Xu, Haifeng Deng, Lujun Chen, Jingting Jiang
Abstract
suppressing CXCL1-mediated activation of cell cycle, indicating that the regulation of H3K36me3 level by targeting SETD2 and/or the administration of downstream CXCL1 might represent a potential therapeutic way for new treatment in LUAD.
Topics & Concepts
CXCL1Histone methyltransferaseCancer researchMethyltransferaseAdenocarcinomaHistoneChemistryCell biologyBiologyInternal medicineMedicineMethylationChemokineReceptorBiochemistryGeneCancerEpigenetics and DNA MethylationRNA modifications and cancerLung Cancer Research Studies