A novel ROS-activable self-immolative prodrug for tumor-specific amplification of oxidative stress and enhancing chemotherapy of mitoxantrone
Hongjie Zhang, Weijian Chen, Jing Wang, Wenxiang Du, Bibo Wang, Lei Song, Yuan Hu, Xiaopeng Ma
Topics & Concepts
Oxidative stressTumor microenvironmentReactive oxygen speciesProdrugMitoxantroneGlutathioneChemistryCancer cellApoptosisCancer researchPharmacologyBiochemistryCancerChemotherapyBiologyTumor cellsEnzymeGeneticsNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliverySulfur Compounds in Biology