Neurological Manifestations and their Correlated Factors in COVID-19 Patients; a Cross-Sectional Study.
Farzad Ashrafi, Davood Ommi, Alireza Zali, Sina Khani, Amirali Soheili, Mehran Arab Ahmadi, Behdad Behnam, Shabnam Nohesara, Farbod Semnani, Alireza Fatemi, Mehri Salari, Reza Jalili Khoshnood, Mohammad Vahidi, Niloofar Ayoobi‐Yazdi, Saeed Hosseini Toudeshki, Elham Sobhrakhshankhah
Abstract
INTRODUCTION: COVID-19 might present with other seemingly unrelated manifestations; for instance, neurological symptoms. This study aimed to evaluate the neurologic manifestations and their correlated factors in COVID-19 patients. METHODS: This retrospective observational study was conducted from March 17, 2020 to June 20, 2020 in a tertiary hospital in Iran. The study population consisted of adult patients with a positive result for COVID-19 real-time reverse transcriptase polymerase chain reaction (RT-PCR) using nasopharyngeal swabs. Both written and electronic data regarding baseline characteristic, laboratory findings, and neurological manifestations were evaluated and reported. RESULTS: saturation was significantly lower in patients with neurological manifestations (p = 0.04). In addition, medians of neutrophil count (p = 0.006), neutrophil-lymphocyte ratio (NLR) (p = 0.02) and c-reactive protein (CRP) (p = 0.001) were significantly higher and the median of lymphocyte count (p = 0.03) was significantly lower in patients with neurological manifestations. CONCLUSION: The prevalence of neurological manifestations in the studied cases was high (55.4%). This prevalence was significantly higher in older age, grated BMI, longer lasting disease, and opium usage.