Herpes Simplex Virus 1 ICP34.5 Alters Mitochondrial Dynamics in Neurons
Richard Manivanh, Jesse Mehrbach, Audra J. Charron, Andrew V. Grassetti, Stacey Cerón, Sean A. Taylor, Jorge Rubén Cabrera, Scott A. Gerber, David A. Leib
Abstract
Herpes simplex virus persists lifelong in neurons and can reactivate to cause recurrent lesions in mucosal tissues. A key determinant of virulence is the viral protein ICP34.5, of which residues 68 to 87 significantly contribute to neurovirulence through an unknown mechanism. Our report provides evidence that residues 68 to 87 of ICP34.5 are required for binding mitochondrion-associated factors. These interactions alter mitochondrial dynamics in neurons, thereby facilitating viral replication and pathogenesis.
Topics & Concepts
BiologyMitochondrionAutophagyCell biologyProgrammed cell deathHerpes simplex virusApoptosisMitophagyViral replicationVirusBiochemistryVirologyHerpesvirus Infections and TreatmentsMosquito-borne diseases and controlToxoplasma gondii Research Studies