β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund’s adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway
Feng Zhang, Zhiyu Liu, Xijing He, Zhanqi Li, Bin Shi, Fengmei Cai
Abstract
and decreased the expression of NF-κB, RANKL, STAT3. In conclusion, β-sitosterol SLN showed the antiarthritic effect via suppression of NF-kB and activation of HO-1/Nrf-2 pathway.
Topics & Concepts
RANKLArthritisMedicineEndocrinologyInternal medicineVascular endothelial growth factorTumor necrosis factor alphaInterleukinChemistryPharmacologyImmunologyCytokineActivator (genetics)ReceptorVEGF receptorsSystemic Lupus Erythematosus ResearchCholesterol and Lipid MetabolismCytokine Signaling Pathways and Interactions