Mitochondrial uncouplers induce proton leak by activating AAC and UCP1
Ambre M. Bertholet, Andrew M. Natale, Paola Bisignano, Junji Suzuki, Andriy Fedorenko, James Hamilton, Tatiana Brustovetsky, Lawrence Kazak, Ryan Garrity, Edward T. Chouchani, Nickolay Brustovetsky, Michael Grabe, Yuriy Kirichok
Topics & Concepts
ThermogeninChemistry2,4-DinitrophenolMitochondrionBiophysicsBioenergeticsBiochemistryMechanism of actionInner mitochondrial membraneCoenzyme Q – cytochrome c reductaseThermogenesisBiologyCytochrome cAdipose tissueIn vitroAdipose Tissue and MetabolismMitochondrial Function and PathologyATP Synthase and ATPases Research