Pandemic influenza A (H1N1) virus causes abortive infection of primary human T cells
Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang, Shuai Liu, Ying Zheng, Shengrui Mu, Xiaoyan Deng, Xiaohui Zou, Yeming Wang, Xiao Shang, Dan Cui, Lixue Huang, Xiaoxuan Feng, William J. Liu, Bin Cao
Abstract
T cells, which indicate the mechanism of intracellular antiviral activities for inhibition of virus replication such as abnormal viral splicing efficiency, incomplete life cycles and up-regulation of interferon-stimulated genes in human T cells. These findings provide insights into understanding lymphopenia and the infectious mechanisms of pandemic influenza A virus and broad immune host-pathogen interactional atlas in primary human T cells.
Topics & Concepts
BiologyVirologyVirusImmune systemCytotoxic T cellInfluenza A virusCD8Viral replicationInterferonImmunologyGeneticsIn vitroInfluenza Virus Research StudiesImmune Cell Function and InteractionT-cell and B-cell Immunology