Designing antibacterial polymeric systems: (co)poly(2-oxazoline) conjugates with acyclic and macrocyclic polyamino polycarboxylic chelators
Marcelina Bochenek, Barbara Mendrek, Agnieszka Kowalczuk, Wojciech Wałach, Łukasz Jałowiecki, Jacek Borgulat, Grażyna Płaza, Jerzy Kubacki, Marcin Sikora, Agnieszka Fus-Kujawa, Łukasz Sieroń, Katarzyna Gawron, Natalia Oleszko-Torbus
Abstract
. Using cytometric analysis, we further investigated the ability of the obtained systems to disrupt the bacterial cell membrane, demonstrating the permeability of the outer bacterial membrane (OM) after POx-DOTA treatment, and the disruption of the OM and the inner membrane (IM) after POx-DTPA treatment. The designed macromolecular systems also remained non-toxic to human skin fibroblasts in a wide range of concentrations, making them promising candidates for further studies on antibacterial biomaterials.
Topics & Concepts
ConjugateOxazolineChemistryCombinatorial chemistryPolymer chemistryOrganic chemistryCatalysisMathematicsMathematical analysisSynthesis and biological activitySynthesis of β-Lactam CompoundsPhosphorus compounds and reactions