Discovery of estrogen receptor α targeting caged hypoxia-responsive PROTACs with an inherent bicyclic skeleton for breast cancer treatment
Baohua Xie, Bin Xu, Lilan Xin, Yizhou Wei, Xinyi Guo, Chune Dong
Topics & Concepts
Estrogen receptorChemistryHypoxia (environmental)Breast cancerPharmacologyCancer researchCancer cellLigand (biochemistry)CytotoxicityReceptorCancerInternal medicineMedicineBiochemistryIn vitroOrganic chemistryOxygenProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis