Hexosomes as Efficient Platforms for Possible Fluoxetine Hydrochloride Repurposing with Improved Cytotoxicity against HepG2 Cells
Hend Mohamed Abdel‐Bar, Shaymaa Elsayed Khater, Dalia Ghorab, Abdulaziz Mohsen Al-mahallawi
Abstract
FH release, where only 19.5 ± 2.3% released in phosphate-buffered saline (PBS) pH 7.4 after 24 h. Contrarily, HEX rapidly released FH in acetate buffer pH 5.5 and achieved a 90.5 ± 4.7% release after 24 h. The obtained HEX showed an improved cellular internalization in a time-dependent manner and enhanced the cytotoxicity (2-fold higher than FH solution). The current study suggests the potential of FH-HEX as a possible anticancer agent against hepatocellular carcinoma.
Topics & Concepts
CytotoxicityChemistryPoloxamerParticle sizeOleic acidHydrochlorideIn vitroNuclear chemistryChromatographyCombinatorial chemistryBiochemistryOrganic chemistryCopolymerPhysical chemistryPolymerLung Cancer Research StudiesNeuroendocrine Tumor Research AdvancesProteoglycans and glycosaminoglycans research