Association between Inflammatory Bowel Disease and Pancreatitis: A PRISMA-Compliant Systematic Review
Pengfan Li, Kanjun Chen, Zheng Mao, Yue Luo, Yan Xue, Yuli Zhang, Xueying Wang, Lihang Zhang, Sizhen Gu, Danbo Dou
Abstract
Background/Objectives . This systematic review was conducted to investigate the association between pancreatitis and IBD. Methods . MEDLINE, Embase, and CENTRAL were systematically searched for correlative studies till 2 November 2019. RevMan5.3 was used to estimate relevance. Results . Three studies with 166008 participants were included. The risk of pancreatitis significantly increased in the patients with CD (OR, 3.40; 95% CI, 2.70-4.28;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.00001</mml:mn></mml:math>) and UC (OR, 2.49; 95% CI, 1.91-3.26;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.00001</mml:mn></mml:math>). Increased risks of CD (OR, 12.90; 95% CI, 5.15-32.50;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.00001</mml:mn></mml:math>) and UC (OR, 2.80; 95% CI, 1.00-7.86;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M4"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.05</mml:mn></mml:math>) were found in patients with chronic pancreatitis. As for patients with acute pancreatitis, there were significant association of CD (OR, 3.70; 95% CI, 1.90-7.60;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M5"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0002</mml:mn></mml:math>), but were not UC. Conclusions . The evidence confirmed an association between pancreatitis and IBD. When pancreatitis patients have chronic diarrhea and mucus blood stool or IBD patients have repeated abdominal pain and weight loss, they should consult pancreatic and gastrointestinal specialists.