Carrier-free nanomedicines self-assembled from palbociclib dimers and Ce6 for enhanced combined chemo-photodynamic therapy of breast cancer
Zheng Huang, Huaisong Hu, Tong Xian, Zhigang Xu, Dianyong Tang, Bochu Wang, Yimei Zhang
Abstract
values of Palb-TK-Palb/Ce6 NPs in MDA-MB-231 cells were around 1-2 μM and 2 μM and the Palb-TK-Palb/Ce6 NPs showed an increase in apoptosis up to 91.9%. In general, the carrier-free nanomedicine self-assembled from palbociclib dimers and Ce6 provides options for combinatorial chemo-photodynamic therapy.
Topics & Concepts
PalbociclibPhotodynamic therapyCancerBreast cancerCancer researchMedicineOncologyMaterials scienceChemistryInternal medicineMetastatic breast cancerOrganic chemistryAdvanced Breast Cancer TherapiesNanoplatforms for cancer theranosticsNanocluster Synthesis and Applications