ROS-responsive dexamethasone micelles normalize the tumor microenvironment enhancing hypericin in cancer photodynamic therapy
Ruifeng Liang, Ka Hong Wong, Yan Yang, Yourong Duan, Meiwan Chen
Abstract
released HYP was excited, enabling ROS production, which resulted in effective cell apoptosis. Moreover, the upregulated ROS further cleaved the micelles, thus achieving the subsequent self-circulating burst release of HYP and DXM for PDT. Notably, real-time accumulation and elimination of drugs can be monitored owing to the red fluorescence property of HYP. This facile design not only provides a platform for cancer theranostics, but also offers a feasible strategy to combat cancer in an integral way.
Topics & Concepts
Photodynamic therapyHypericinChemistryPhotosensitizerReactive oxygen speciesTumor microenvironmentCancer researchMicelleAngiogenesisDrug deliveryPharmacologyCancer cellBiophysicsCancerBiochemistryMedicineInternal medicineBiologyPhotochemistryTumor cellsAqueous solutionPhysical chemistryOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer, Hypoxia, and Metabolism