Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments
Ahmed A. Al‐Karmalawy, Mahmoud Rashed, Marwa Sharaky, Hamada S. Abulkhair, Mohamed M. Hammouda, Haytham O. Tawfik, Moataz A. Shaldam
Topics & Concepts
ChemistryHead and neck squamous-cell carcinomaIC50Cell cultureApoptosisDoxorubicinGrowth inhibitionCancerCancer cellCell growthCellPharmacologyCancer researchIn vitroHead and neck cancerStereochemistryBiochemistryChemotherapyInternal medicineBiologyMedicineGeneticsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and Biological EvaluationCancer therapeutics and mechanisms