Inactivation of <i>ackA</i> and <i>pta</i> Genes Reduces GlpT Expression and Susceptibility to Fosfomycin in <i>Escherichia coli</i>
Hidetada Hirakawa, Ayako Takita, Yumika Sato, Suguru Hiramoto, Yusuke Hashimoto, Noriyasu Ohshima, Yoji Andrew Minamishima, Masami Murakami, Haruyoshi Tomita
Abstract
genes responsible for the acetic acid metabolism system reduced GlpT expression and fosfomycin activity. In other words, this study shows a new genetic mutation that leads to fosfomycin resistance in bacteria. The results of this study will lead to further understanding of the mechanism of fosfomycin resistance and the creation of new ideas to enhance fosfomycin therapy.
Topics & Concepts
FosfomycinEscherichia coliMutantMicrobiologyBiologyGeneMutationAntibioticsGeneticsAntibiotic Resistance in BacteriaUrinary Tract Infections ManagementEscherichia coli research studies