An Update on Self-Amplifying mRNA Vaccine Development
Anna K. Blakney, Shell Ip, Andrew J. Geall
Abstract
This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects.
Topics & Concepts
Computational biologyVector (molecular biology)VirologyBiologyComputer scienceMedicineImmunologyGeneticsRecombinant DNAGeneRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesImmunotherapy and Immune Responses