The effect of local passive heating on skeletal muscle histamine concentration: implications for exercise-induced histamine release
Joshua E. Mangum, Karen Wiedenfeld Needham, Dylan C. Sieck, Matthew R. Ely, Emily A. Larson, Mairin Peck, Christopher T. Minson, John R. Halliwill
Abstract
The "exercise signal" that triggers histamine release within active skeletal muscle during aerobic exercise is unknown. By mimicking the magnitude and time course of increasing skeletal muscle temperature observed during aerobic exercise, we demonstrate that part of the exercise-induced rise in histamine is explained by a thermal effect, with in vitro experiments suggesting this is most likely via de novo histamine formation. This thermal effect may be important in generating positive adaptations to exercise training.
Topics & Concepts
HistamineSkeletal muscleHistidine decarboxylaseInternal medicineEndocrinologyChemistryDegranulationMast cellMedicineImmunologyHistidineBiochemistryEnzymeReceptorExercise and Physiological ResponsesMast cells and histamineAllergic Rhinitis and Sensitization