Radicicol Inhibits Chikungunya Virus Replication by Targeting Nonstructural Protein 2
Sangwoo Nam, Yun Ji Ga, Joo‐Youn Lee, Woo-Yeon Hwang, Eunhye Jung, Jin Soo Shin, Wei‐Yi Chen, Gildon Choi, Bin Zhou, Jung‐Yong Yeh, Yun Young Go
Abstract
modeling analyses determined that G641D mutation in the methyltransferase (MT)-like domain of nsP2 is essential for its interaction with cytoplasmic Hsp90β chaperone. Our findings collectively support the potential application of radicicol as an anti-CHIKV agent. The detailed study of the underlying mechanism of action further contributes to our understanding of virus-host interactions for novel therapeutics against CHIKV infection.
Topics & Concepts
BiologyChikungunyaVirologyViral replicationIn silicoVirusAlphavirusAntiviral drugGeneticsGeneHeat shock proteins researchViral Infections and VectorsMosquito-borne diseases and control