KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma

Hui Xu, Chuan Shao

2020OncoTargets and Therapy24 citationsDOI Open Access PDF

Abstract

Abstract: With the rapid development of detection methods, next-generation sequencing (NGS) technology as a new technology, some novel epidermal growth factor receptor (EGFR) gene fusions comprising the EGFR linked to various fusion partners, most commonly RAD51 , are detected in the non-small cell lung cancer (NSCLC). We described a case of an unreported kinesin family member 5B ( KIF5B )- EGFR in NSCLC and the efficacy of EGFR tyrosine kinase inhibitors (TKIs) to this specific fusion. Considering this rare EGFR fusion and remarkable response to EGFR-TKI, we should realize the importance of these rare EGFR fusions, the advances in diagnostic techniques and personalized care for lung cancer patients. Keywords: non-small cell lung cancer, adenocarcinoma, KIF5B-EGFR , EGFR-TKIs, next-generation sequencing

Topics & Concepts

Epidermal growth factor receptorLung cancerCancer researchMedicineAdenocarcinomaTyrosine kinaseFusion geneMutationCancerOncologyInternal medicineGeneReceptorBiologyGeneticsLung Cancer Treatments and MutationsMicrotubule and mitosis dynamicsHER2/EGFR in Cancer Research

&lt;p&gt;&lt;em&gt;KIF5B&lt;/em&gt;-&lt;em&gt;EGFR&lt;/em&gt; Fusion: A Novel &lt;em&gt;EGFR&lt;/em&gt; Mutation in Lung Adenocarcinoma&lt;/p&gt;

Abstract

Topics & Concepts

<p><em>KIF5B</em>-<em>EGFR</em> Fusion: A Novel <em>EGFR</em> Mutation in Lung Adenocarcinoma</p>