Camphor sulfonic acid catalyzed a simple, facile, and general method for the synthesis of 2-arylbenzothiazoles, 2-arylbenzimidazoles, and 3<i>H</i>-spiro[benzo[<i>d</i>]thiazole-2,3′-indolin]-2′-ones at room temperature
Gurpreet Kaur, Radha Moudgil, Mussarat Shamim, Vivek K. Gupta, Bubun Banerjee
Abstract
A simple, mild, eco-friendly, general, and convenient approach has been developed for the synthesis of structurally diverse 2-arylbenzothiazole derivatives from the reactions of 2-aminothiophenol and various aromatic aldehydes using camphor sulfonic acid a low cost, commercially available, efficient organo-catalyst in aqueous ethanol at room temperature. Under the same optimized conditions, a series of 2-arylbenzimidazoles was also synthesized starting from o-phenylenediamines and various aldehydes whereas synthesis of 3H-spiro[benzo[d]thiazole-2,3′-indolin]-2′-ones was accomplished from the reactions of 2-aminothiophenol and substituted isatins.
Topics & Concepts
ChemistryCamphorCatalysisThiazoleOrganic chemistrySulfonic acidCombinatorial chemistryAqueous solutionSynthesis and biological activityMulticomponent Synthesis of HeterocyclesSulfur-Based Synthesis Techniques