Synthesis of Borylated Carbocycles by [2 + 2]-Cycloadditions and Photo-Ene Reactions
Jarett M. Posz, Neetu Sharma, Paige A. Royalty, Yanyao Liu, Christophe Salomé, Thomas C. Fessard, M. Kevin Brown
Abstract
Saturated bicyclic compounds make up a valuable class of building blocks in the development of agrochemicals and pharmaceuticals. Here, we present the synthesis of borylated bicyclo[2.1.1]hexanes via crossed [2 + 2]-cycloaddition. Due to the presence of the C-B bond, a variety of structures can be easily prepared that are not accessible by other methods. Moreover, a rare photo-ene reaction is also disclosed, allowing for the diastereoselective synthesis of trisubstituted borylated cyclopentanes.
Topics & Concepts
ChemistryCyclopentanesBicyclic moleculeEne reactionCycloadditionCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryCatalysisRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques