Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation
Feng‐Liang Liu, Kaixin Wu, Jiaoyang Sun, Zilei Duan, Xiongzhi Quan, Junqi Kuang, Shilong Chu, Wei Pang, Han Gao, Ling Xu, Ying-Chang Li, Hai-Lin Zhang, Xuehui Wang, Rong‐Hua Luo, Xiaoli Feng, Hans R. Schöler, Xinwen Chen, Duanqing Pei, Guangming Wu, Yong‐Tang Zheng, Jiekai Chen
Abstract
The research can be used to generate animal models of severe disease based on the hACE2 mice for development of treatment against severe COVID-19 and also quickly establish specific mouse models in response to other emergency situations in the future.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)ComplementationBiology2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyAnimal modelHumanized mouseDiseaseImmunologyGeneticsMedicineGeneInfectious disease (medical specialty)Internal medicineOutbreakPhenotypeImmune systemEndocrinologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesVirus-based gene therapy research