Ligand-free nickel catalyzed perfluoroalkylation of arenes and heteroarenes
Shubham Deolka, Ramadoss Govindarajan, Serhii Vasylevskyi, Michael C. Roy, Julia R. Khusnutdinova, Eugene Khaskin
Abstract
a radical pathway. The catalytic protocol is distinguished by its simplicity, and its wide scope demonstrates the potential in the late-stage functionalization of drug analogues and peptides.
Topics & Concepts
CatalysisLigand (biochemistry)Combinatorial chemistryChemistryNickelSurface modificationScope (computer science)AdductOrganic chemistryComputer scienceReceptorBiochemistryPhysical chemistryProgramming languageFluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods