Sulfonylimination of Proline with Sulfonylazides Involving Aldehyde-Induced Decarboxylation Coupling
Hongyan Liu, Zengfen Pang, Liqiang Hao, Jian Sun, Zheng Zhang, Fuqiang Wen, Chengcai Xia
Abstract
In the presence of aldehyde, a facile method was developed to obtain N-sulfonyl amidines under metal- and oxidant-free conditions by the decarboxylative of proline. This transformation features a double C–N bond formation and allows for the green synthesis of the N-sulfonyl amidines on the basis of mild conditions.
Topics & Concepts
ChemistrySulfonylDecarboxylationAldehydeProlineCombinatorial chemistryOrganic chemistryAmino acidCatalysisBiochemistryAlkylSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions