The Peroxisome Proliferator-Activated Receptors of Ray-Finned Fish: Unique Structures, Elusive Functions
Evridiki Boukouvala, Grigorios Krey
Abstract
The Actinopterygian and specifically the Teleostean peroxisome proliferator-activated receptors (PPARs) present an impressive variability and complexity in their structures, both at the gene and protein levels. These structural differences may also reflect functional divergence from their mammalian homologs, or even between fish species. This review, taking advantage of the data generated from the whole-genome sequencing of several fish species, highlights the differences in the primary structure of the receptors, while discussing results from the literature pertaining to the functions of fish PPARs and their activation by natural and synthetic compounds.
Topics & Concepts
BiologyFish <Actinopterygii>ReceptorPeroxisomePeroxisome proliferator-activated receptorComputational biologyGenomePeroxisome proliferatorGeneEvolutionary biologyDivergence (linguistics)GeneticsFisheryLinguisticsPhilosophyPeroxisome Proliferator-Activated ReceptorsAquaculture disease management and microbiotaAdipose Tissue and Metabolism