Litcius/Paper detail

Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia

Zhimin Gu, Yuxuan Liu, Yuannyu Zhang, Hui Cao, Junhua Lyu, Xun Wang, Annika Wylie, Simon J. Newkirk, Amanda E. Jones, Michael Lee, Giovanni A. Botten, Mi Deng, Kathryn E. Dickerson, Cheng Cheng Zhang, Wenfeng An, John Abrams, Jian Xu

2021Nature Genetics113 citationsDOIOpen Access PDF

Topics & Concepts

RetrotransposonBiologyGene silencingMyeloid leukemiaEpigeneticsEctopic expressionTransposable elementGeneticsDNA methylationLong terminal repeatPhenotypeMyeloidCancer researchGenomeGeneGene expressionChromosomal and Genetic VariationsCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniques