Mechanism of allosteric inhibition in the Plasmodium falciparum cGMP-dependent protein kinase
Jung Ah Byun, Katherine Van, Jinfeng Huang, Philipp Henning, Eugen Franz, Madoka Akimoto, Friedrich W. Herberg, Choel Kim, Giuseppe Melacini
Abstract
PKG-selective inhibitors for improved management of malaria.
Topics & Concepts
Allosteric regulationPlasmodium falciparumMechanism (biology)Protein kinase AcGMP-dependent protein kinaseChemistryCell biologyKinaseBiologyMitogen-activated protein kinase kinaseBiochemistryEnzymeMalariaImmunologyEpistemologyPhilosophyComputational Drug Discovery MethodsMalaria Research and ControlBioactive Compounds and Antitumor Agents