Preleukemic and leukemic evolution at the stem cell level
Jacob Stauber, John M. Greally, Ulrich Steidl
Abstract
Hematological malignancies are an aggregate of diverse populations of cells that arise following a complex process of clonal evolution and selection. Recent approaches have facilitated the study of clonal populations and their evolution over time across multiple phenotypic cell populations. In this review, we present current concepts on the role of clonal evolution in leukemic initiation, disease progression, and relapse. We highlight recent advances and unanswered questions about the contribution of the hematopoietic stem cell population to these processes.
Topics & Concepts
Somatic evolution in cancerBiologyStem cellPopulationHaematopoiesisDiseaseLeukemiaPreleukemiaEvolutionary biologyGeneticsImmunologyCancerMedicinePathologyEnvironmental healthAcute Myeloid Leukemia ResearchAcute Lymphoblastic Leukemia researchHematopoietic Stem Cell Transplantation