Topical Insulin in Neurotrophic Keratopathy: A Review of Current Understanding of the Mechanism of Action and Therapeutic Approach
Marcin Karcz, Anna Lorenc, Rafał Leszczyński, Ewa Mrukwa–Kominek
Abstract
Neurotrophic keratopathy is a corneal disease characterized by impaired corneal innervation. It can lead to corneal epithelial defects, ulcerations, and perforations. Topical insulin has been shown to be effective in treating this disorder. Insulin is a growth factor that can promote corneal epithelial cell proliferation and migration. In addition, it can also inhibit corneal epithelial cell apoptosis. Topical insulin has previously been found to enhance corneal wound healing. This article reviews the current understanding of the mechanism of action of topical insulin in the treatment of neurotrophic keratopathy.
Topics & Concepts
Neurotrophic factorsMedicineMechanism (biology)InsulinMechanism of actionCorneal DiseasesNeurotrophinCorneal epitheliumDiseaseBullous keratopathyCorneaOphthalmologyNeuroscienceEndocrinologyInternal medicineBiologyReceptorEpistemologyPhilosophyIn vitroBiochemistryOcular Surface and Contact LensCorneal Surgery and TreatmentsCorneal surgery and disorders