Discovery and characterization of novel potent BCR-ABL degraders by conjugating allosteric inhibitor
Haixia Liu, Qianglong Mi, Xinyu Ding, Chencen Lin, Linyi Liu, Chaowei Ren, ShuTing Shen, Yubao Shao, Jinju Chen, Yongqi Zhou, Liting Ji, Heqiao Zhang, Fang Bai, Xiaobao Yang, Qianqian Yin, Biao Jiang
Topics & Concepts
Chemistrybreakpoint cluster regionPonatinibK562 cellsAllosteric regulationCancer researchABLFusion proteinIbrutinibMutantTyrosine kinaseMutationLeukemiaBiologyGeneticsBiochemistryDasatinibSignal transductionReceptorCellChronic lymphocytic leukemiaGeneRecombinant DNAProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsPeptidase Inhibition and Analysis