Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca <sup>2+</sup> mobilization and the inflammatory activity of dendritic cells
Laura Marongiu, Francesca Mingozzi, Clara Cigni, Roberta Marzi, Marco Di Gioia, Massimiliano Garrè, Dario Parazzoli, Laura Sironi, Maddalena Collini, Reiko Sakaguchi, Takashi Morii, Mariacristina Crosti, Monica Moro, Stéphane Schurmans, Tiziano Catelani, Rany Rotem, Miriam Colombo, Stephen B. Shears, Davide Prosperi, Ivan Zanoni, Francesca Granucci
Abstract
R3 and for NFAT nuclear translocation. Pharmacological inhibition of ITPKB in mice reduced both LPS-induced tissue swelling and the severity of inflammatory arthritis to a similar extent as that induced by the inhibition of NFAT using nanoparticles that delivered an NFAT-inhibiting peptide specifically to phagocytic cells. Our results suggest that ITPKB may represent a promising target for anti-inflammatory therapies that aim to inhibit specific DC functions.