Litcius/Paper detail

Discovery of GPX4 inhibitors through FP-based high-throughput screening

Yu Cao, Bin Wu, Ying Xu, Mingchen Wang, Xinyu Wu, Xiaochen Liang, Jin Lin, Zhihai Li, Hua Lin, Cheng Luo, Shijie Chen, Shijie Chen

2023European Journal of Medicinal Chemistry16 citationsDOI

Topics & Concepts

ChemistryGPX4SelenocysteinePhospholipid-hydroperoxide glutathione peroxidaseBiochemistrySelenoproteinGlutathione peroxidaseGlutathioneEnzymeCysteineFerroptosis and cancer prognosisCancer, Lipids, and MetabolismInflammatory mediators and NSAID effects