Nanoscale Metal–Organic Layer Isolates Phthalocyanines for Efficient Mitochondria-Targeted Photodynamic Therapy
Geoffrey T. Nash, Taokun Luo, Guangxu Lan, Kaiyuan Ni, Michael Kaufmann, Wenbin Lin
Abstract
nMOL for PDT. Upon irradiation, SBU-bound ZnOPPc PSs absorb 700 nm light and efficiently sensitize the formation of singlet oxygen by preventing aggregation-induced self-quenching of ZnOPPc excited states. With intrinsic mitochondria-targeting capability, ZnOPPc@nMOL showed exceptional PDT efficacy with >99% tumor growth inhibition and 40-60% cure rates on two mouse models of colon cancer.
Topics & Concepts
Singlet oxygenChemistryPhotodynamic therapyPhthalocyanineSBusPhotosensitizerPhotochemistryNanoscopic scaleZincQuantum yieldQuenching (fluorescence)Absorption (acoustics)Aqueous solutionBiocompatibilityFluorescenceNanotechnologyOxygenMetal-organic frameworkOrganic chemistryMaterials scienceAdsorptionQuantum mechanicsComposite materialPhysicsNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine ChemistryPhotodynamic Therapy Research Studies