Brain temperature affects quantitative features of hippocampal sharp wave ripples
Peter Petersen, Mihály Vöröslakos, György Buzsáki
Abstract
During physiological conditions, brain temperature fluctuates approximately 3°C between sleep and active waking. Here, we show that features of hippocampal ripples, including the rate of occurrence, peak frequency, and duration are correlated with brain temperature variations. Focal bidirectional manipulation of temperature in the hippocampal CA1 region in awake rodents show that ripple frequency can be altered in the direction expected from the correlational observations, implying that temperature plays a significant role.
Topics & Concepts
Hippocampal formationNeuroscienceBrain wavesHippocampusPsychologyPhysicsCommunicationElectroencephalographyCircadian rhythm and melatoninStress Responses and CortisolNeural dynamics and brain function