Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance
Tomoaki Inazumi, Kiyotaka Yamada, Naritoshi Shirata, Hiroyasu Sato, Yoshitaka Taketomi, Kazunori Morita, Hirofumi Hohjoh, Soken Tsuchiya, Kentaro Oniki, Takehisa Watanabe, Yutaka Sasaki, Yuichi Oike, Yasuhiro Ogata, Junji Saruwatari, Makoto Murakami, Yukihiko Sugimoto
Abstract
-EP4 pathway sustains basal lipolysis as a negative feedback loop of insulin action, and perturbation of this process leads to "metabolically healthy obesity." The potential role of the human EP4 receptor in lipid regulation was also suggested through genotype-phenotype association analyses.
Topics & Concepts
LipolysisInsulin resistanceAdipose tissueEndocrinologyInternal medicineProstaglandin E2FibrosisInsulinDeposition (geology)MedicineChemistryBiologySedimentPaleontologyAdipose Tissue and MetabolismLipid metabolism and biosynthesisCardiovascular Disease and Adiposity