Pushing the Limits on the Intestinal Crossing of Metal–Organic Frameworks: An <i>Ex Vivo</i> and <i>In Vivo</i> Detailed Study
Sara Rojas, Tania Hidalgo, Zhongrui Luo, David Ávila‐Brande, Anna Laromaine, Patricia Horcajada
Abstract
intestinal model (rat) is used to further support the nanoMOFs' bypass across the intestinal barrier, demonstrating a fast crossing (only 2 h). To the best of our knowledge, this report on the intestinal crossing of intact nanoMOFs sheds light on the safe and efficient application of MOFs as oral DDSs.
Topics & Concepts
BiocompatibilityEx vivoIn vivoNanotechnologyNanocarriersBioadhesiveDrug deliveryBioavailabilityMaterials scienceBiophysicsChemistryPharmacologyMedicineBiologyBiotechnologyMetallurgyMetal-Organic Frameworks: Synthesis and ApplicationsNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics