CuF<sub>2</sub>/DMAP-Catalyzed N-Vinylation: Scope and Mechanistic Study
Krishanu Mondal, Susanta Patra, Pallabi Halder, Narottam Mukhopadhyay, Parthasarathi Das
Abstract
CuF2/DMAP has been established as an excellent catalytic system for vinylsilane-promoted N-vinylation of amides and azoles at room temperature without an external fluoride source. A mechanism has been proposed on the basis of the isolation of reactive intermediate [Cu(DMAP)4Cl2], fluoride ion-assisted transmetalation, and ultraviolet–visible spectroscopic studies. The catalytic efficiency of the synthesized and structurally characterized [Cu(DMAP)4Cl2] complex has been demonstrated. The valuable monomers for water-soluble polymers, viz., NVP, NVC, and NVIBA, were synthesized on a gram scale.
Topics & Concepts
ChemistryCatalysisTransmetalationFluorideMonomerCombinatorial chemistryPolymer chemistryPolymerPhotochemistryOrganic chemistryInorganic chemistryChemical Synthesis and AnalysisFluorine in Organic ChemistryAsymmetric Hydrogenation and Catalysis