Clearance of β-amyloid and synapses by the optogenetic depolarization of microglia is complement selective
Zezhong Lv, Lixi Chen, Ping Chen, H. Peng, Yi Rong, Wei Hong, Qiang Zhou, Nan Li, Boxing Li, Rosa Chiara Paolicelli, Yang Zhan
Topics & Concepts
MicrogliaOptogeneticsDepolarizationNeurosciencePhagocytosisSynapseChannelrhodopsinBiologyCell biologyBiophysicsInflammationImmunologyNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsBarrier Structure and Function Studies