Telescoped Continuous Flow Synthesis of Optically Active γ-Nitrobutyric Acids as Key Intermediates of Baclofen, Phenibut, and Fluorophenibut
Sándor B. Ötvös, Patricia Llanes, Miquel À. Pericàs, C. Oliver Kappe
Abstract
-generated performic acid-mediated aldehyde oxidation. Simple access to valuable optically active substances is provided with key advances in terms of productivity and sustainability compared to those of previous batch approaches.
Topics & Concepts
ChemistryEnantioselective synthesisOptically activePerformic acidCombinatorial chemistryOrganic chemistryCatalysisInnovative Microfluidic and Catalytic Techniques InnovationAnalytical Chemistry and ChromatographyMicrofluidic and Capillary Electrophoresis Applications