An enzyme-responsive Gp1a-hydrogel for skin wound healing
Chunming Zhao, Yangyi Dong, Jialin Liu, Hongxing Cai, Zhouru Li, Xiaoming Sun, Wenjiang Yin, Jingyuan Ma, Hongmei Liu, Shanshan Li
Abstract
Faster recovery and fewer scars are ideal wound healing. We have demonstrated that the cannabinoid receptor 2 (CB 2 ) agonist Gp1a is beneficial to skin wound healing, which inhibits inflammation and fibrogenesis while promoting re-epithelialization. However, the systemic administration is imprecise and overqualified for a local skin wound. Herein, we prepared Gp1a-gel using triglycerol monostearate (Tm) hydrogel and detected whether the Gp1a-gel worked effectively on mouse skin excision wounds. The results showed that Gp1a-gel might sustainably increase the CB 2 for at least 8 days. It decreased inflammation and fibrogenesis while promoting wound enclosure and re-epithelialization. These results suggested Gp1a-gel may utilize as a potential formulation strategy to treat the skin wound.