HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
Marcin J. Suskiewicz, Florian Zobel, T.E.H. Ogden, Pietro Fontana, A. Ariza, Ji‐Chun Yang, Kang Zhu, Lily Bracken, William Hawthorne, Dragana Ahel, David Neuhaus, Ivan Ahel
Topics & Concepts
PARP1Poly ADP ribose polymeraseDNA damageADP-ribosylationNAD+ kinasePolymeraseChromatinSerineDNA repairDNAAllosteric regulationChemistryPARP inhibitorBiochemistryBiologyMolecular biologyCell biologyEnzymePARP inhibition in cancer therapyDNA Repair MechanismsToxin Mechanisms and Immunotoxins