Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells <i>in vivo</i> and <i>in vitro</i>
Miao Bai, Mengqi Cui, Mingyue Li, Xinlei Yao, Yulun Wu, Lihua Zheng, Luguo Sun, Qiuhang Song, Shuyue Wang, Lei Liu, Chunlei Yu, Yanxin Huang
Abstract
experiments demonstrated that compared to the control, Z31216525 significantly inhibited tumor growth and showed very low toxicity. Further mechanistic studies revealed that Z31216525 may exert an antitumor effect by inhibiting the expression of the c-Myc gene. Collectively, our studies identified a novel HDACi that is expected to become a new potential therapeutic drug for EOC and has important value for the design of new HDACi structures.
Topics & Concepts
In vivoOvarian cancerIn vitroCarcinogenesisAcetylationCancer researchHistoneBiologyApoptosisCancer cellHistone deacetylaseCancerChemistryBiochemistryGeneGeneticsHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsUbiquitin and proteasome pathways