Telomeric DNA–RNA-hybrid G-quadruplex exists in environmental conditions of HeLa cells
Hong‐Liang Bao, Yan Xu
Abstract
F NMR approach to study the association of telomere RNA and DNA in vitro and in living human cells. We successfully characterized the DNA-RNA hybrid G-quadruplex (HQ) structure formed by telomeric DNA and RNA. We further demonstrated for the first time that an HQ conformation can exist in the environmental conditions of HeLa cells.
Topics & Concepts
HeLaG-quadruplexDNARNAChemistryMolecular biologyComputational biologyBiologyCellBiochemistryGeneDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery