Hydrophosphorylation of electron-deficient alkenes and alkynes mediated by convergent paired electrolysis
Xue Sun, Jianjing Yang, Kelu Yan, Xinyu Zhuang, Jie Yu, Xiaodan Song, Fanjun Zhang, Bingwen Li, Jiangwei Wen
Abstract
A straightforward and practical strategy for hydrophosphorylation of electron-deficient alkenes and alkynes to access γ-ketophosphine oxides, enabled by a convergent paired electrolysis (CPE) in the absence of a metal, base, and redox reagent, has been described. Mechanistic studies have revealed that the diarylphosphane oxides play the dual role of a phosphorus radical precursor and hydrogen donor in this transformation.
Topics & Concepts
ReagentRedoxCombinatorial chemistryChemistryElectrolysisBase (topology)ElectronMetalOrganic chemistryElectrodePhysicsPhysical chemistryMathematicsQuantum mechanicsElectrolyteMathematical analysisAsymmetric Hydrogenation and CatalysisOrganophosphorus compounds synthesisChemical Synthesis and Analysis