Litcius/Paper detail

Therapeutic targeting of the mevalonate–geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer

Chenchen Guo, Ruijie Wan, Yayi He, Shuhai Lin, Jiayu Cao, Ying Qiu, Tengfei Zhang, Qiqi Zhao, Yujia Niu, Yujuan Jin, Hsin‐Yi Huang, Xue Wang, Li Tan, Roman K. Thomas, Hua Zhang, Luonan Chen, Kwok‐Kin Wong, Liang Hu, Hongbin Ji

2022Nature Cancer107 citationsDOI

Topics & Concepts

Mevalonate pathwayChemotherapyStatinLung cancerMedicineCancer researchAutophagyCancerPharmacologyBiologyApoptosisOncologyInternal medicineEnzymeBiochemistryReductaseCancer, Lipids, and MetabolismATP Synthase and ATPases ResearchRNA modifications and cancer