Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies
Janin Lautenschläger, Sara Wagner-Valladolid, Amberley D. Stephens, Ana Fernández‐Villegas, Colin Hockings, Ajay Mishra, James D. Manton, Marcus Fantham, Meng Lü, Eric J. Rees, Clemens F. Kaminski, Gabriele S. Kaminski Schierle
Abstract
can influence protein homeostasis of cytosolic aggregation-prone proteins. We propose that approaches that seek to maintain mitochondrial fitness, rather than target downstream mitochondrial dysfunction, may aid in the search for therapeutic strategies to manage PD and related neuropathologies.
Topics & Concepts
ProteostasisMitochondrionCell biologyProteasomeReactive oxygen speciesBiologyProtein aggregationProteasesAmyloid (mycology)BiochemistryChemistryEnzymeBotanyParkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatmentsNeurological diseases and metabolism