TRPV1: Structure, Endogenous Agonists, and Mechanisms
Miguel Benítez‐Angeles, Sara L. Morales‐Lázaro, Emmanuel Juárez-González, Tamara Rosenbaum
Abstract
The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel. Nonetheless, detailed mechanisms and description of binding sites have been resolved only for a few endogenous agonists. This review focuses on summarizing discoveries made in this particular field of study and highlighting the fact that studying the molecular details of activation of the channel by different agonists can shed light on biophysical traits that had not been previously demonstrated.
Topics & Concepts
Transient receptor potential channelTRPV1EndogenyIon channelChemistryNeuroscienceReceptorCell biologyBiophysicsBiologyBiochemistryIon Channels and ReceptorsPain Mechanisms and TreatmentsHerbal Medicine Research Studies