The complete catalytic mechanism of xanthine oxidase: a computational study
Pedro Miguel Gomes Ribeiro, Henrique S. Fernandes, Luísa B. Maia, Sérgio F. Sousa, José J. G. Moura, Nuno M. F. S. A. Cerqueira
Abstract
In this article, quantum mechanical/molecular mechanical (QM/MM) methods were used to study the full catalytic mechanism of xanthine oxidase (XO).
Topics & Concepts
Xanthine oxidaseMechanism (biology)CatalysisChemistryComputational chemistryEnzymeBiochemistryPhysicsQuantum mechanicsGout, Hyperuricemia, Uric AcidPorphyrin Metabolism and DisordersBiochemical and Molecular Research