Discovery of FtsZ inhibitors by virtual screening as antibacterial agents and study of the inhibition mechanism
Ruo‐Lan Du, Ning Sun, Yik-Hong Fung, Yuan-Yuan Zheng, Yu Wai Chen, Pak‐Ho Chan, Wing‐Leung Wong, Kwok‐Yin Wong
Abstract
S2727 (Dacomitinib) was virtually screened out from a compound library via targeting the PC 190723 binding site of FtsZ and its inhibition effect on the functions of FtsZ was demonstrated by biological assays.
Topics & Concepts
FtsZVirtual screeningAntimicrobialMechanism of actionDocking (animal)In vivoMechanism (biology)Drug discoveryChemistryCell divisionIn vitroDrug developmentComputational biologyDrugBiologyMicrobiologyCellPharmacologyBiochemistryGeneticsMedicinePhilosophyNursingEpistemologyAntibiotic Resistance in BacteriaBacteriophages and microbial interactionsPneumonia and Respiratory Infections