Outer Membrane Vesicles Transmitting <i>bla</i> <sub>NDM-1</sub> Mediate the Emergence of Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae
Bin Tang, Awen Yang, Peilin Liu, Zhiqian Wang, Zijuan Jian, Xia Chen, Qun Yan, Xianghui Liang, Wenen Liu
Abstract
and deliver resistance genes to other K. pneumoniae strains, even hvKP. The transfer of carbapenem genes into hypervirulent strains may promote the emergence and dissemination of CR-hvKP. This study elucidates a new mechanism underlying the formation of CR-hvKP.
Topics & Concepts
Klebsiella pneumoniaeMicrobiologyMeropenemBiologyVirulenceCarbapenemBacterial outer membraneHorizontal gene transferGeneMultiple drug resistanceEnterobacteriaceaeAntibiotic resistanceVirologyDrug resistanceAntibioticsEscherichia coliGenomeGeneticsBacterial Infections and VaccinesPneumonia and Respiratory InfectionsAntibiotic Resistance in Bacteria